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It can but in general its discouraged because it seems to introduce molds more quickly.
Anyway, you can also go cheap and just use paper towels. Rip of 4 or 5, stack them on the bottom of the terra and then mist them with a plant mister. It works as good as perlite and its easier to cleanup afterwards. I usually refresh the towels between every flush.
I don't trust the perlite either - I always spray everything with alcoholic disinfectant, also the perlite. Then of course you have to wait until it's dried out before you put anything on it