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Ne crois pas que les shops vendent en fonction de la faible toxicité hein.Chips a dit:Le 2-FA est vraiment sympa.
Je sais pas pourquoi il circule pas plus dans les shop RC.
On en sait rien sur sa toxicité, mais pas mieux pas pire que les 3/4 des autres RC...
salut, peut-être qu'il n'es tout simplement pas assez populaire et aurait donc un rendement financier moindre ?Chips a dit:Le 2-FA est vraiment sympa.
Je sais pas pourquoi il circule pas plus dans les shop RC.
On en sait rien sur sa toxicité, mais pas mieux pas pire que les 3/4 des autres RC...
Epsil a dit:Et j'aime bien les courgettes, on oublie trop souvent que ça se mange ces trüks là.
Okay, so 4-FA neurotoxicity is a hot topic nowadays and most of people know very little about it and spread disinformation. I'm not claiming to be a pharmacist, nor a doctor, but these studies back up my claims. Now read:
First thing needed to know is, that effects of halogenated amphetamines are different in rat brains compared to human, so we can't apply every research on rats to humans. http://www.ncbi.nlm.nih.gov/pubmed/17038507
Second thing I want to address is 4-FA comparison to chlorinated amphetamine, such as 4-CA. 4-CA is not neurotoxic in humans! 4-CA has been used as an antidepressant in the seventies.
Considerable clinical application of 4-CA has been made, and it has been found effective as an antidepressant when used chronically at levels of 75 mg/day (van Praag et al., 1971; van Praag and Korf, 1976). There are very few side effects noted and the drug is tolerated very well. However, indications of raphe-nucleus degeneration (Yunger et al., 1974) and related neurotoxicity (Harvey and McMaster, 1976) in experimental animals have discouraged further clinical study.
The same applies to 4-CMA
The N-methyl homolog of 4-chlorophenylisopropylamine (80, para-chloromethamphetamine p-CMA, Ro 4-6861, S-33) was also found to be a potent and long-lasting depleter of brain serotonin (Fuller et al., 1965). It has been compared with methamphetamine in normal subjects (Verster and van Praag, 1970) and has been evaluated clinically in comparison with 4-CA (79) as an antidepressant (Deniker et al., 1971; van Praag et al., 1971; van Praag and Korf, 1976). Typical dosages were between 60 and 90 mg/day, administered chronically for several weeks. There appeared to be no physical or psychic dependence developed, no cardiovascular complications, and no sleep or appetite problems.
Third thing is, para-halogenated amphetamines deplete serotonin, but in a reversible way in humans, compared to irreversible in rats.
This finding indicated that p-fluoroamphetamine might share with p-chloroamphetamine the action that is responsible for short-term 5-HT depletion but lack the property of p-chloroamphetamine required for long-term effects. A later study confirmed that p-fluoroamphetamine was less potent than p-chloroamphetamine in depleting brain 5-HT (Harvey et al., 1977; Fuller, 197.
With 4-chloroamphetamine and 4-bromoamphetamine, the depletion of brain 5-hydroxyindoles lasted for at least a week. 4-Fluoroamphetamine, in contrast, lowered serotonin and 5-hydroxyindoleacetic acid levels only for short times (2–6 hr) after drug injection, and 5-hydroxyindole levels were essentially back to normal within 24 hr.
The failure of 4-fluoroamphetamine to produce a long-lasting depletion of brain serotonin like that produced by 4-chloroamphetamine or 4-bromoamphetamine may reflect the inability of the fluoro-compound to be metabolized in the same way as the other haloamphetamines.
You see? 4-FA doesn't deplete serotonin in rat brain in irreversible way.
Speculation alert: Looking at the atom radius, there's a chance that 4-FA is less neurotoxic than regular amphetamine, since data shows that serotonine depletion goes in hand with atom radius in para (4) position. http://www.ncbi.nlm.nih.gov/pubmed/15677348
Further reading:
http://www.erowid.org/archive/rhodiu...a.sar.hop.html
http://www.sciencedirect.com/science...28390875900994
http://www.ncbi.nlm.nih.gov/pubmed/14654099
http://bitnest.ca/Silo42/10.1111/j.1....tb31518.x.pdf (FULL TEXT)
TL;DR
1. 4-CA is not neurotoxic in humans, it's been proven to be safe in doses 75-90mg/day for a year. Same applies to methylated version.
2. Serotonin levels get back to normal in 24 hours after 4-FA indigestion, compared to ONE WEEK after 4-CA indigestion (and bigger halogenated amphetamines)
3. Therefor 4-FA is nothing like other halogenated amphetamines.
4. 4-FA has lesser addictive potential than plain old amphetamine, due to longer half-life
stoned-fr a dit:MP, et tu peux aussi mater ce qu'on a dit sur le topic du 2-fa.