69Ron's "Triple E" Tek: Elemicin Extraction from Elemi Oil

[magickpencil]

magickpencil: Per usual, this is all anecdotal ; don't take SWIM's word for it--SWIM is taking SWIS's word for it!
Regardless, this an interesting read
You'll find the source here: The DMT-Nexus » 69Ron's "Triple E" Tech for Elemicin Extraction from Elemi Oil

EDIT: DMSO INTRODUCES PROBLEMS WITH ELEMICIN DIGESTION AND NEGATIVELY AFFECTS THE EXPERIENCE. TO SOLVE THIS ISSUE WITH THE TECH, BEFORE USE ALWAYS DILUTE THE FINAL EXTRACT AS STATED BELOW.

VERSION 1.2

There are a few extraction techs available on the net. Here’s one that is all over the place:

Elemicin (4-allyl-l,2,6-trimethoxy benzene), C12H1603, constitutes the principal constituent of Manila elemi oil, in which it was discovered by Semmler1) who also gave it its name. It is found in fraction 277 to 280° of elemi oil.2) In order to isolate elemicin, the fraction in question is boiled for half an hour with formic acid. As Semmler has demonstrated by experiments made on anethol and safrol, allyl compounds remain unchanged, whereas propenyl compounds are destroyed.

While good to know, it’s not practical for most people.

SWIM did a test last night, and seems to have stumbled upon a simpler kitchen tech for concentrating the elemicin found in Elemi oil.

Here are the steps for 1 dose (0.5 ml, or about 18 drops).

69Ron's "Triple E" Tech for Elemicin Extraction from Elemi
1 - measure out 0.5 ml of 100% pure therapeutic grade Elemi essential oil and put in a small micro beaker (or any other suitable container).

2 - measure out 2.5 ml of the standard DMSO available at the health food stores (this DMSO is 99.9% pure DMSO mixed with 30% water, so it’s actually 70% DMSO) and add it to the Elemi oil.

3 - Mix the two liquids thoroughly for about 1 minute. Then let it sit for a few seconds. After a while the two liquids separate into two distinct layers. The clear bottom layer contains most of the elemicin. The sedative compound and a bunch of other junk in the Elemi oil remains in the top yellowish layer. NOTE: Before mixing, the top Elemi oil layer is yellowish and glows greenish blue in UV light while the bottom DMSO layer is clear and doesn't glow in UV light. But after mixing and settling, the top yellowish layer no longer glows in UV light, but instead the bottom clear DMSO layer glows greenish blue in UV light, indicating one or more components have almost completely migrated into the bottom DMSO layer.

4 - Separate the top yellowish layer from the clear bottom layer and discard the top yellowish layer. The clear bottom layer is your end product containing the elemicin. An easy way to separate the layers is by using a 5 ml glass pipette. A standard separatory funnel is simply too large to use for this. A micro separatory funnel would be fine, but honestly a pipette works very well. You could even use an HDPE plastic pipette for this.

Simply drink the DMSO DILUTED IN 1 CUP OF MILK or some other liquid.

Don't take the DMSO directly. If taken directly, the effects of the elemcin will be inferior, far less psychedelic, less euphoric, and it will have more stimulant effects, and may cause muscle tension in some people. It needs to be diluted. The more, the better. Apparently DMSO causes a lot of the elemicin to soak into your flesh and bypass the digestive system. It seems to be necessary for elemicin to be digested properly in order get its LSD-like effects. There is a theory that elemicin is aminated to TMA when properly digested. Concentrated DMSO would prevent this from happening to a good portion of the elemicin. While it's just a theory that elemicin is aminated to TMA in the digestive system, tests done by several of SWIM's friends seem to indicate that something like this is happening. So don't use the DMSO directly. Always dilute it before use.

After extracting the elemi oil into the DMSO, the foggy sedated withdrawn feeling of whole Elemi oil had at large doses is no longer present. Only the desired psychedelic elemicin seems to be active in the DMSO layer. But remember to dilute the DMSO prior to use.

5ml DMSO & 1ml elemi oil before separation (super macro) // Image by q21q21 / source

How does this tech work?
If we look at the XLogP data for the various compounds found in Elemi essential oil, we can see that elemicin has a very low XLogP and should be soluble in DMSO, while a vast majority of the other compounds present in large amounts have a high XLogP value and will not be soluble in DMSO.

Compounts in Elemi oil likely soluble in DMSO:

00.2% Carvone                  XLogP3-AA 2.4
00.3% Methyl eugenol           XLogP3    2.5 
03.5% Elemicin                 XLogP3    2.5
02.5% 1,8-Cineole (Eucalyptol) XLogP3    2.5 
00.6% Terpinolene              XLogP3-AA 2.8 
00.4% gamma-Terpinene          XLogP3-AA 2.8 
00.4% alpha-Pinene             XLogP3-AA 2.8

Compounts in Elemi oil likely insoluble in DMSO:

15.1% alpha-Phellandrene       XLogP3-AA 3.2 
54.1% Limonene                 XLogP3-AA 3.4 
00.8% beta-Phellandrene        XLogP3-AA 3.4 
01.5% para-Cymene              XLogP3    4.1 
02.4% Myrcene                  XLogP3-AA 4.3 
15.0% Elemol                   XLogP3-AA 4.4

Everything with an XLogP of 3.2 and up seems to be insoluble in DMSO. Since this is the majority of the oil, most of the oil is removed. Only about 5-10% of the oil remains in the DMSO. How much remains in the DMSO after mixing will depend on the oil used. Oil with a high elemicin content will lose a larger percentage to the DMSO.

The myrcene which is removed by this tech is very likely the main sedative component of the oil. Myrcene is the main active compound of lemongrass. The data shows that it should be active as a sedative in Elemi oil in doses as low as 14 drops. Because of myrcene’s high XLogP, it is insoluble in DMSO. The other compounds removed including limonene, alpha-phellandrene, beta-phellandrene, para-cymene, and elemol are most likely to be inactive at the dosage range present in 10-20 drops of elemi oil. I feel confident that myrcene is the compenent responsible for most of the sedation felt in Elemi oil doses above 12 drops. It’s the only sedative compound present in Elemi oil that I know is active at such a small doses.

While the extract produced by this tech is not pure elemicin, it’s effects are dramatically cleaner than whole Elemi oil. Very few of the compounds soluble in DMSO are active at the small amounts present. Elemicin is apparently very potent, being the most active compound in whole Elemi oil, despite it being present in pretty small amounts. By removing the non DMSO soluble compounds, we effectively remove about 90-95% of the oil, leaving elemicin and eucalyptol (1,8-cineole) in the DMSO as the primary compounds. With eucalyptol being many times less potent than elemicin, its effects are virtual absent from the experience had from using the DMSO. For eucalyptol to be an effective sedative you need about 2 ml of it. With Elemi oil containing only about 2.5% eucalyptol, you’d need 80 ml of Elemi oil to get an effect from the eucalyptol in it, while you need only 0.1-0.5 ml of Elemi oil to get an effect from the elemicin. So clearly the eucalyptol present in the DMSO is not going to do anything at doses high enough to get a decent elemicin trip.

Eucalyptol Contamination Causing Sedation in the End Product?
The main sedative in the oil is myrcene, but this is removed by this tech. If your Triple E extract is still sedating, it’s very likely contaminated with a lot of eucalyptol. After doing some research, I found that some elemi oil is pretty high in eucalyptol. Eucalyptol will be extracted along with elemicin using this tech. It is difficult to remove it.

Like myrcene, eucalyptol will interfere with the psychedelic effects of elemicin, and some people are apparently very sensitive to the effects of eucalyptol, only needing a drop to feel it!

Eucalyptol has the following actions: antiseptic, antispasmodic, depressant, expectorant.

Side effects from eucalyptol include: headache, lightheadedness, sedation, respiratory depression, vomiting, drop in blood pressure, circulation problems, collapse, and asphyxiation.

Eucalyptol is something you don’t want to ingest in high amounts. If your end product is still sedating, it’s most likely contaminated with lots of eucalyptol, or you are very sensitive to eucalyptol. My advice, don’t up the dose if you feel sedation. Find a different source of elemi oil, one that is high in elemicin and low in eucalyptol. Elemi oil that is high in elemicin smells like nutmeg and roses. The end product of this extract should smell strongly of nutmeg.

Does this work with nutmeg oil?
SWIM has not tried this with nutmeg oil. It may possibly help cleanup the nutmeg oil experience. However the XLogP3 of myristicin is 2.9, so it might not get all of the myristicin out of the oil. It would however get most of the elemicin out (it has an XLogP3 of 2.5 so it’s more soluble in DMSO).

 

[IJesusChrist]

Interesting, I never heard of elemicin or elemi oil...

Basically, to add to all of this, since elemicin is butted off at 280°, and DMSO @ 189°C, you could just distill it.

Of course, if you don't have glass ware or a good proper hot plate or a thermometer with that high of temperature, you might just want to drink dmso..... :\


there are reports that eugenol causes cancer, but uh, I'm pretty sure its a bunch of BS. On level with benzene causing cancer (laff).

 

[magickpencil]

Elemi oil is steam distilled from resin of the elemi tree (Canarium luzonicum)

Elemicin is an isolate from this aromatic essential oil
Here is an interesting side by side comparison:

What would the effects of a successful, pure elemnicin trip be like and what would be the dosage, does anyone know?

The psychedelic dose of pure elemicin is around 20-60 mg. It's an oil that sort of smells like nutmeg. Dosage varies from person to person.

SWIM has a friend who received a free sample a while ago from a vendor in China. She ordered it because she was interested in elemi oil and wanted to know if elemicin was the active ingredient in it or not. She tested it on herself first and found out it was active at 20 mg. She later gave it out to several people at a party in 20 mg doses in capsules, a few people took more than 1 capsule. Individual sensitivity to it varies a lot. Some people got nearly no effects from 40 mg, while others had obvious psychedelic effects at 20 mg, one guy nearly freaked out from 20 mg. SWIM also tried it. It's similar to elemi oil that's high in elemicin. So it's clearly the main active in elemi oil. Elemicin is super expensive. SWIM will have to stick with extracting it from elemi oil.

If you have decent elemi oil, and you use the Triple E tech to extract the elemicin, the effects are pretty much identical to pure elemicin, UNLESS your oil is high in eucalyptol, in which case it will cause sedation, a headache, etc. Eucalyptol is a sedative and causes headache and other side effects. Elemicin is an anti-depressant, a hallucnigen, not a sedative.

Here are the known effects of elemicin: antioxidant, hallucinogenic, anti-depressant, anti-histamine, hypotensive (lowers blood pressure), anti-serotonergic.

Pure elemicin would be best, but good quality elemi oil is nearly as good. Some elemi oil can be used as is without extraction and will produce very decent psychedelic effects. Other elemi oil is high in sedatives like myrcene and eucalyptol, and causes sedation and lots of side effects.

Elemicin is one of SWIM's favorite new psychedelics. He's only had it pure 1 time, but a nearly pure Triple E extract is almost just as good.

SWIM is working on a way to remove the eucalyptol. One of his friends has a batch of elemi oil that's very high in eucalyptol (it smells a little like eucalyptus oil and flowers with no nutmeg smell to it), and for that batch the Triple E tech doesn't help much, it still causes sedation, headache, and nausea, and almost no other effects. I almost wonder if she was cheated and sold elemi oil diluted with eucalyptol.

- Source

 

[magickpencil]

SWIM had a very pleasant experience with this oil the other night. He consumed about 3ml, extracted with DMSO according to the 'Triple E' tek (his first attempt was about 1ml). He experienced a very pleasant and mildly psychedelic stimulation. Unfortunately he was in a social setting and did not keep a good record of the experience, which he plans on doing next time.

But it was, as 69Ron has said, very social. He had a great time with his friends. He also drank several beers and smoked hash, so again, this doesn't make for the ideal 'trip report', something he's been meaning to write up for the common good.

- Source

SWIM has already gotten past [the San Pedro-esque come-up] stage with 1 ml. Again SWIM is extra sensitive to all psychedelics. Once you get past that stage, visuals become very obvious, closed eye visuals are also present, and there’s mental psychedelic effects that are unique to it.

The visuals are unique, watery, things sort of look like they are shifting, sliding a little, and there are LSD-style patterns present, but not as strong as LSD, at least at the dose SWIM has used.

SWIM has experienced objects looking unfamiliar as with LSD. SWIM has also experienced a sense of timelessness, or that time is slowing down, like that experienced with LSD. Those effects are very similar to LSD.

The mental effects are not like LSD. The mind is calm, not racing, but there are mental effects. I don’t know how to describe them though.

Alteration of music at 1 ml for SWIM was very noticeable. Music sounded larger, with more depth, more emotion, with a dreamy feel reminiscent of mushrooms.

The only part of the experience SWIM finds similar to phenethylamines (DOM, mescaline) is the body feel, the euphoria, and the socially comfortable feeling it has. In this way it’s totally unlike LSD.

- Source

Here’s the latest trip report from SWIM. He used the Triple E extraction tech for this trip. Note that his elemi oil is extremely low in eucalyptol and very high in elemicin apparently. His oil smells like nutmeg and roses, and when extracted into DMSO, it smells pretty much like nutmeg. This is how you know it’s high in elemicin. Elemicin smells very similar to nutmeg.

Some elemi oil contains a lot of eucalyptol and very little elemicin. When using the Triple E tech eucalyptol will be extracted along with the elemicin. So if there’s a lot of eucalyptol present in your oil you will not get effects like the trip below. Instead, you’ll get a headache, sedation, and lots of side effects. SWIM is lucky so far. Both of his batches of oil have been high in elemicin and low in eucalyptol. But he has a friend that has oil high in eucalyptol, and after the Triple E extraction, the end product smells like eucalyptus, causes sedation, a headache, etc. So don't expect a trip like the one below unless you have elemi oil that's low in eucalyptol like what SWIM has.

SWIM's following trip report was done in the evening.

T+0:00, a 1 ml dose of elemi oil is extracted into 2 ml of DMSO by mixing vigorously, separating and discarding the top oil layer, and then mixing the DMSO with 1 cup of sweetened milk. I drink the milk down quickly.

T+0:10, a mild euphoric stimulant effect is felt.

T+0:15, there’s a lot of bodily tingling sensations. It’s pretty strong, I almost feel like I’m going to get numb, like the feeling you get from an anesthetic, but I never actually get numb. The tingling is pleasant. I go to watch TV on the couch.

T+0:30, it’s about the same just stronger.

T+1:00, there’s a strong sense of unreality present. It’s actually a little creepy. Sounds aren’t quite perceived in the same way. Sounds seem more effected than vision. My mind is shifting from one audio focal point to the next. While watching TV, my mind is repeatedly distracted by ghostly sounds coming from the wind blowing through the window, sounds of footsteps, people talking, etc. As if they suddenly come into great focus and are then hidden from me.

At this point the stimulant effect is more relaxed. The tingling sensations are still there but not as strong. There’s more euphoria present. The overall feel is dreamy, pleasant, relaxed mentally, but also with a light stimulant effect.

Visuals are present. Things look watery and shifty, they are vibrating, and moving slightly. There’s some object size distortion present. The visuals are minor, LSD-like, but the sound alterations are pretty strong.

No side effects of any kind are felt.

T+2:00, it’s already peaked. This is a faster peak than normal. Usually it takes 3 hours.

T+3:00, most of the psychedelic effects are gone. There’s still a lot of euphoria and mild stimulation.

T+6:00, it’s about the same. I go to sleep. I have lots of very detailed dreams during that night

T+12:00, I wake up the next morning feeling refreshed, but the effects of the elemicin are still present. Drinking coffee causes the effects to be more noticeable.

- Source

 

[magickpencil]

Update: Version 1.2 addressing eucalyptol contamination

 

[magickpencil]

From Nutritional Supplements Knowledgebase:

Summary

DMSO is an oily liquid that when applied topically may reduce pain and inflammation in joints and muscles. It's also been shown to promote healing of minor cuts and burns and is a powerful antioxidant. However, it is a highly controversial nutrient, and while it is one of the most studied nutrients, it's also considered one of the most poorly understood.

…

Safety of DMSO

Skin irritation, stomach upset, headache, and sensitivity to light may occur in some cases.

It is important that the area where DMSO is applied as well as the hands applying it be very clean because DMSO is quickly absorbed by the skin, allowing contaminants on the skin to also be absorbed.

It is also important to use highly purified forms of DMSO.
Toxicity of DMSO

Studies on the toxicity of DMSO in humans have shown no serious adverse effects when it is applied topically at or below one gram per kilogram of bodyweight.

 

[IJesusChrist]

I'm intrigued!

 

[magickpencil]

Does SWIY think there would be a problem doing this test two days in a row?

It WILL work, but not nearly as well, about 1/2 as well, and then 1/8, and then hardly work at all.

SWIM’s tests with tetrahydroharmine and harmaline (RIMAs) have confirmed that elemicin’s effects actually last longer than 8 hours. After 8 hours you can barely feel elemicin on its own, but that’s because of built up tolerance to it. It’s still there for at least 2 days following the day of use. Taking harmaline or tetrahydroharmine as much as 2 days after taking elemicin will cause the elemicin effects to be noticeable again. This is proof it’s still present in the body after 2 days.

In SWIM, taking it once every 4 days is the most frequent he can do it without tolerance developing. Once every 3 days is pretty good. Once every 2 days is not so good. Once every day and SWIM develops almost complete tolerance on the 3rd day of use, and on the 4th day it does nothing.

- Source

 

[tazrick]

Hey so theoretically if this would work with the Elemi oil, this would also work with ground nutmeg right? If they both contain the main psychoactive components it should still be soluble in DMSO yes? I already have DMSO and I have Elemi oil coming in the mail, but if I soaked ground nutmeg in DMSO for a while then filter out the nutmeg, would it still extract the psychoactives? I've seen crazy ass teks for nutmeg and it just doesn't seem worth it. Maybe this could be the answer lol.

 

[Bonzoisboss]

Just a question, do we have to add water to the DMSO, or do we have to buy a vial that is 30% water and 70% DMSO?