rofl cannafarmer if you don't know what you're talking about then say nothing instead of confusing everyone.
5-HTP is extracted from a plant (griffonia simplicifolia)). It is the closest precursor to serotonin. Your body produces it's own 5-HTP from L-Tryptophan (which you get in many foods such as bananas). So yes, 5-HTP is 100% natural, it is not a chemical created in a lab, and is not a street drug, it is sold in pharmacies.
I have experienced it combined with weed and it had interesting effects. I don't know if I'll ever try it with shrooms though. I'd like to read a TR of someone who did it though, as I can't find any on erowid.