I tried it last week.
I can say I would definately recommend you to do it in the evening in a quiet environment.
I hadn't eaten meat and diary and stuff the day before and haven't done this 12 hours after.
Also no sex in this period.
And prepare very well mentally, brainstorm, meditate on what you hope to acheive or attain more insight and/or enclaration in
Make it quite a list or actually what I mean is don't underestimate it's potence
Being as mentally prepared as possible will ensure you get the most out of the experience
I did it in the afternoon and it was a beautiful experience, beyond beautiful even. It was holy. But I did feel that the experience would come more to it's element in the evening.
I took about 3,5grs of Peganum Harmala 20 minutes before drinking half of the aya, wich I made by extracting 3 times from 20grs of Mimosa rootbark.
After 10 minutes, I puked after about half a minute of desperately trying to hold it in.
Then it came on.
I might still write a trip report about the most holy and healing psychedelic experience I ever had but I'm a bit buissy atm.
Sometimes its as if it speaks to you
This was the case
It felt like it was god or sth :S or definately some ultimately wise spirit
And as if it was healing me
It was showing me truth, wisdom and insights only so deep as I could just handle.
It/he could share much more with me, but I would'nt have been able to handle this
It went exactly the speed that I could comprehend, as if it was patiently guiding me.. and with such compassion..
I felt like a tiny person with no experience or wisdom whatsoever compared to this energy that was patiently teaching me
It confronts you as well with a lot of bad personality traits and/or habits that you have wrongly constructed along your path.
Some say this can be too confronting but to me this was absolutely not the case
The aya is so compassionate..
When you attain the new insight you can look down on how your old you contructed a trait overlooking things and being misguided by emotion with such compassion..
It does humble you ofc.. but this is beautiful it feels so incredibly real..
In the middle of my trip I drank the rest of the aya and I IMMEDIATELY threw it all up, along with some P harmala.
So I'm quite sure no alkaloids were taken into my body from this last portion and because of this quick throwing up not even all alkaloids from the first portion may have been taken up..
And still I had an incredibly beautiful experience!
So I suppose I still have a lot to look forward to
Next time I think I'll just take the P. Harmala 30 or 40 minutes before, then swallow a capsule with crystal DMT in it.
I want to be sure this time I get a good dose

If you are going to try it I wish you as pleasant and beautiful and healing an experience as I have had!