If this helps: However research has shown that in addition to the effects on serotonin, the combination results in an unexpectedly large amount of dopamine release that far exceeds what one would expect from the DA releasing properties of each drug alone added together. This suggests a strong degree of synergy between the two drugs. [1]
TFMPP has only mild effects when not combined with benzylpiperazine, and it produces aversive effects in animals rather than self-administration, which explains the decision not to permanently make TFMPP an illicit drug.
TFMPP has also been previously reported as a metabolite of the analgesic antrafenine.[6] TFMPP shares some features with fenfluramine.
The dosage commonly used when combined with BZP for "ecstasy-like effects" is between 30 and 100 mg, while higher doses of TFMPP alone cause mildly hallucinogenic effects at around 100–250mg; however, higher doses can cause a range of side effects including migraine headaches, muscle aches, nausea and vomiting, as well as a come-down syndrome characterised by insomnia, loss of appetite, and headache; these side effects tend to discourage abuse of TFMPP.
