5g Dried + 1.5g Syrian Rue, What to expect

[JustinNed]

Hey guys, I plan on taking between 5 and 7g dried mushies this weekend with about 1.5g Syrian Rue.
Was just wondering if anyone had any for warnings or expectations?

 

[GOD]

Have fun and tell us what happens . A comparison to that amount of mushrooms without the MAOI would be cool to .

 

[endlessness]

did you research this combination, like read other people's experiences and so on? i remember quite a few people they had negative overwhelming experiences when mixing MAOIs and mushrooms...

why not just take more mushrooms?

but do what you want of course, and take care of set and setting. and tell us how it went

or smoke some dmt on mushrooms, now THAT is a positively overwhelming experience

 

[Caduceus Mercurius]

Jonathan Ott said MAO inhibitors, herbs like Valerian and substances like diazepam (Valium) will only weaken a trip, not strengthen it. These substances are all antagonists to psilocybin, DMT and LSD. He explains the principles behind that here (starting at 2:45): Jonathan Ott on ayahuasca analogues

The only reason why MAO inhibitors are taken, is to make oral absorption possible.

Still, many people have reported that the combination of MAOi and mushrooms resulted in a stronger mushroom trip, so perhaps it does somehow (don't ask me how) increase the amount of psilocybin that is absorbed. It could also be a placebo effect.

 

[Forkbender]

MAOI's have an effect on their own. It could well be that the heightened sensitivity of the mushroom experience makes these effects stronger and that therefore the trip is experienced as being stronger.

 

[maxfreakout]

Still, many people have reported that the combination of MAOi and mushrooms resulted in a stronger mushroom trip, so perhaps it does somehow (don't ask me how) increase the amount of psilocybin that is absorbed. It could also be a placebo effect.

in my experience it is a very strong combination, it more than doubles the intensity of the mushrooms


there's an article about it by James Kent here:
http://leda.lycaeum.org/?ID=16337

 

[Ultima]

in my experience it is a very strong combination, it more than doubles the intensity of the mushrooms

i agree.. i would REALLY like to know how this trip turns out. iv mixed mao with mush only about 4 times.. the highest dose iv done with mao was 2.5G with 2G mao... ya... lets just say its pretty intense.. be ready for a LONG trip!

 

[JustinNed]

Those are words of encouragment I like to read lol.

You suppose 1g of Rue would be enough to inhibit MAO?

 

[GOD]

One has to take at least 3 grams to inhibit the MAO in the stomach . IF what your talking about works the effects dont come from inhibiting MAO in the stomach it can , theoreticaly , only come from stoping the Psilocin getting destroyed in the brain . Or as Fork said the subtle physical effects that MAOIs have on the body and consciousness are magnifyed by the trip . Up till now i havent seen any sensible explanation as to why or how MAOIs could interact with the Psilocin itself to change the trip .

 

[Horrigan]

I'm thinking about trying nutmeg on shrooms. It's said to be a light MAOI.
Tell us if it's great, I think I'll get some Syrian Rue too.

 

[GOD]

James Kent makes a claim but offers no proof and no explanation of how what he says should work .

 

[Ultima]

One has to take at least 3 grams to inhibit the MAO in the stomach.

thats not true.

 

[GOD]

Tell us more ? Or are you picking hairs . One needs to eat that much to activate DMT wich has a chemical structure similar to Psilocybin and Psilocin . Of cource less will cause some MAO inhibition but would it be enough to activate anything ? Tell us more ?

 

[maxfreakout]

i took 2 grams of rue with mushrooms and it definitly felt like my mao was inhibited

 

[GOD]

I`m not argueing that it doesnt . What i`m saying is that up to now i havent seen any scientific explanation of how or why it could potentiate psilocybin / psilocin and i have read in dfferent places from several scientists that it cant .

 

[Horrigan]

Maybe they inhibit reuptake of tryptamins like they do with serotonin (which is close in structure), it would explain it.

 

[maxfreakout]

i have read in dfferent places from several scientists that it cant .

i disagree with this ^

i think that what you have read from these scientists, is merely establishing the fact that psilocybin is active WITHOUT an mao inhibitor, which is obvious and common knowledge. Because of stearic hindrance the mao cant see the psilocybin. But maybe the mao only partially breaks down psiloybin so when it is inhibited you get a stronger trip

 

[GOD]

" Because of stearic hindrance the mao cant see the psilocybin. But maybe the mao only partially breaks down psiloybin so when it is inhibited you get a stronger trip"

How can it break it down if it cant see it ?

 

[maxfreakout]

" Because of stearic hindrance the mao cant see the psilocybin. But maybe the mao only partially breaks down psiloybin so when it is inhibited you get a stronger trip"

How can it break it down if it cant see it ?

maybe it can 'partly' see it, 'hindrance' does not imply complete stoppage

which enzyme is responsible for metabolising psilocybin? Maybe mao-inhibitors partly inhibit this enzyme

 

[GOD]

I dont know but if MAOIs can potentiate or alter the effects of Psilocybin / Psilocin i`d like to know for sure and i`d like to know how . I hope its , if it is anything , not toxicity . Please keep your eyes and ears open and if you hear anything let us know .