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fuckin way different mayn, but if you want a real down home experience go with the natural varieties like cacti, mush and datura...Call it personal preferance, but I find more spiritual value in actual organic plants than in chemical/chemical extracts.
It's a cactus, fuck mayn. You can dose at like 20 bucks a pop, just order it. Then at least you'll be sure and save yourself a fuckload of finger pricks.