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Nux Vomica
#1
L'albero originario dello Sri Lanka, Indonesia, contiene nei semi queste due molecole mortali e TOSSICHE.

Però, in dosi moderate è considerato in India come nootropico-tonico mentale.

Le due molecole sono:

Brucina:


[Image: 200px-Brucina_struttura.svg.png]

(LD[SUB]50[/SUB] (rats, oral) 1 mg/kg, LD[SUB]50[/SUB] (rabbit, oral) 4 mg/kg)

Strictina:

[Image: 150px-Strychnine_formula.png]

la dose mortale media (più esattamente la LD[SUB]50[/SUB]) è di 1 mg/kg.

Capite bene che con 50mg siete stecchiti oppure quasi, in preda convulsioni di qualsiasi tipo.

Però ecco Ron ci viene in aiuto, e ci dice gli effetti:

Citation :Strychnine was once extremely popular as a stimulant. If it wasn't so easy to OD on it, it would still be popular. The downside is its potency. It's just way too potent. You can feel 100 micrograms of it. It's nearly as potent as LSD is. It also has effects that are mind expanding, much like LSD has, but it's not hallucinogenic at all. It makes you see clearer, hear better, improves your sense of touch, things smell stronger. Sex is better. It makes you more aware of things around you. It improves your memory and concentration. It doesn't have the edginess of caffeine. It's one of the best stimulants there is, but also the most toxic. That's the downside.

E ci dice come fare una tintura:

Citation :You need to be very careful making a tincture of Nux Vomica. An active safe adult dose is commonly 10-50 mg of powdered seed. They contain 1.54-5.3% alkaloids. About 1/2 is strychnine, with the rest mostly brucine. An average nut contains 1.23% strychnine and 1.55% brucine. 5.3% alkaloid content is the maximum known to exist.

A dose of 1-3 mg of strychnine was often given by doctors for stimulant usage in adults. In India, doses of 10-50 mg of powdered seed is usually used for the same purpose. 50 mg contains on average 615 micrograms of strychnine and 775 micrograms of brucine.

50 mg of the most potent seeds containing 5.3% alkaloids (usually 50% or less is strychnine) could at most contain 2.65 mg of strychnine, but it's usually more than 50% brucine so you're more likely to get a maximum of only 1.325 mg of strychnine from that much seed.

Activity is solely based on the strychnine content because it's many times more potent than brunice.

A fatal adult dose of strychnine is said to be 30-120 mg orally (much less if injected). Keep in mind that doctors routinely gave patients up to 3 mg several times a day. With 50 mg of seed containing less than 3 mg it is well within the safety zone.

Strychnine is SWIM's favorite stimulant. He uses 500 micrograms at most. Often just 100 micrograms is enough.

If you're going to make a tincture, which SWIM has done, you need to be very careful. It's next to impossible to grind the seeds to a powder. If you inhale the powder, you could get an overdose and die. You don't want to grind the seeds while dry. You don't want any powder in the air.

Here's how to do it safely.


NUV VOMICA 1:50 TINCTURE

1) Put 1 gram of seeds (usually about 1 seed is 1 gram) in 50 ml of vinegar. Let soak covered for 5 days.

2) Remove seed with tweezers. Carefully slice into small pieces using a small knife. Do not touch it with your hands. Using a mortar and pestle grind the pieces to a paste with 1 gram of lactose as a grinding aid. Without the lactose it's very hard to grind to a paste.

3) Scrape the paste out of the mortar using a small spoon (don't touch it). Place in a jar. Rinse out the mortar with the used vinegar from step 1 a little at a time, and add the vinegar to the jar. With all the paste and vinegar in the jar, carefully mix it. Then cap the jar and let sit overnight. Shake it periodically.

4) Filter out the solids. Measure the vinegar so that you have 50 ml exactly. If you have a little less, add some more until you have 50 ml exactly.


If using 1 gram of seeds for 50 ml of vinegar then 1 dose is 1 ml of vinegar, with the potency of 20 mg of seeds. That will contain on average 246 micrograms of strychnine. That's plenty enough for decent stimulant effects. Even half that would be pretty decent.

You don't want to take a dose higher than 50 mg of seeds ever. In India, 50 mg of seed is the maximum safe dose for adults. Don't over do it. An overdose is extremely painful, and deadly. With a 1:50 tincture, 2.5 ml equals 50 mg of seed. Never take more than that.

Keep in mind that you DO NOT WANT TO GRIND DRY SEEDS. That is very dangerous. If you breathe in a cloud of powdered seed dust, you could easily be killed from it, or so I've heard. The reason I posted this tech is because I don't want people trying to extract it and getting hurt. Only grind the seeds when they are thoroughly moistened. That way it's impossible to generate a cloud of deadly Nux vomica dust. Besides, it's next to impossible to grind them when they are dry. You could very easily damage your herb grinder. They are one of the hardest things in the plant kingdom to grind. When wet, with the aid of lactose, it's not that hard. That's the way to do it.

Also, DO NOT TOUCH ANYTHING while extracting. Don't touch the wet seeds with your hands. Don't touch the vinegar the seeds were soaking in. Strychnine can soak into your skin.

Also, DO NOT PROCESS MORE THAN 1 GRAM AT A TIME. Doing a larger batch is very dangerous. With 1 gram, if you accidentally spilled everything and got strychnine all over you, you're likely to be ok. 1 gram would contain about 12 mg of strychnine on average. If that much spilled on you, you're likely to be ok. Most would be easily washed off. But if you were processing a ton of seeds and you spilled a bunch on yourself...well, you get the picture.



Non esistono tinture vendute in europa che io sappia, solo rimedi omeopatici che danno effetti.
E' uno dei pochi stimolanti che ovviamente non viene preso in considerazione, perchè basta poco per una overdose.

Occhio sempre Confusednakeman:
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#2
all'apparenza sembrerebbero mandarini..

[Image: 15261]
' a écrit :dio balla / god dances

ed è felice / and he's happy


Albert Einstein:

«
Tutto è energia e questo è tutto quello che esiste. Sintonizzati alla frequenza della realtà che desideri e non potrai fare a meno di ottenere quella realtà. Non c’è un’altra via. Questa non è filosofia. Questa è fisica.»

«Everything is energy and that’s all there is to it. Match the frequency of the reality you want and you cannot help but get that reality. It can be no other way. This is not philosophy. This is physics.»

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#3
Se dicessi che a pelle non mi sembra proprio così invitante? :?
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#4
Non lo è infatti, la strictina è come l'atropina, bisogna sapere quello si sta facendo.

Per fortuna non è una cosa che si trova facilmente, io l'ho postato per il buon gusto di informare delle presenza di questo stimolante(a volte mortale).


Chimicamente non è una molecola che si trova spesso, è una rarità.
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#5
Nono, per la molecola si capisce che è giusto per fare buona informazione... Io dicevo proprio il frutto: insomma, almeno per me non vedrei alcun rischio di ingestione accidentale (e non credo di essere l'unico) :lol:

Edit: Già leggendo mi era parso probabile, ora ho cercato la molecola e infatti ho confermato il dubbio... Si chiama stricNina Wink
(e un tempo si trovava tranquillamente in alcuni tonici, ma proprio per la sua tossicità venne rimossa dal commercio)
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#6
non è che silver è pagan sotto mentite spoglie?
tutto falso e tutto inventato:lol:
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#7
Citation :Some plants used in Unani system of medicine are toxic, even deadly poisonous. The drugs having such plants as their components are detoxified before they are dispensed to the patients. One such drug, capsule Hudar, has Strychnos nux-vomica L. (Azraqi) seeds as one of its components and is very effectively used to elevate blood pressure. Ancient manuscripts describe many methods of its detoxification. It has been found that the detoxification processes studied reduce the strychnine content, as determined either by using uv-vis spectrophotometer or HPLC, present in Strychnos nux vomica seeds which is responsible for Strychnos nux vomica toxicity. The decrease in strychnine amount was best when the seeds were immersed for detoxification in excess of water for 5 days, in milk for 2 days followed by their boiling in milk. Strychnine in small amounts has been reported to give subjective feeling of stimulation.

Strychnos nux-vomica seeds: Pharmacognostical standardization, extraction, and antidiabetic activity

Citation :Loganin is one of the best-known of the iridoid glycosides.It is named for the Loganiaceae,having first been isolated from the seeds of a member of that plant family,namely those of Strychnos nux-vomica the strychnine tree.It also occurs in Alstonia boonei(Apocynaceae),[1] a medicinal tree of West Africa and in the medicinal/entheogenic shrub Desfontainia spinosa (Columelliaceae) native to Central America and South America.


Loganin is one of the best-known of the iridoid glycosides.It is named for the Loganiaceae,having first been isolated from the seeds of a member of that plant family,namely those of Strychnos nux-vomica the strychnine tree.It also occurs in Alstonia boonei(Apocynaceae),[SUP][1][/SUP] a medicinal tree of West Africa and in the medicinal/entheogenic shrub Desfontainia spinosa (Columelliaceae) native to Central America and South America.

[Image: 150px-Loganin-.png]

Citation :Loganin exhibits CNS-exciting and analgesic activity and holds a key position in the biogenesis of certain indole alkaloids of the type occurring in Yohimbe : Pausinystalia johimbe (formerly known as Corynanthe yohimbe) (Rubiaceae),a medicinal tree found in tropicalWest Africa noted for its aphrodisiac properties.
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#8
Molto molto interessante, Ron e' sempre un grande! Per caso c'e' qualche psiconauta che si trova o sta per andare in India? Big Grin
"But how can the one liberate the many? By first liberating his own being. He does this not by elevating himself, but by lowering himself. He lowers himself to that which is simple, modest, true; integrating it into himself, he becomes a master of simplicity, modesty, truth. Completely emancipated from his former false life, he discovers his original pure nature, which is the pure nature of the universe. Freely and spontaneously releasing his divine energy, he constantly transcends complicated situations and draws everything around him back into an integral oneness. Because he is a living divinity, when he acts, the universe acts." Lao Tzu

"It’s too early for a science. What we need now are the diaries of explorers. We need many diaries of many explorers so we can begin to get a feeling for the territory." T. McKenna

"The man who dies before he dies, does not die when he dies." A. a Sancta Clara


ATTENZIONE! Tutti i miei post sono scritti a puro titolo informativo e non vogliono incitare in alcun modo all'utilizzo di sostanze stupefacenti e/o psicotrope!
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#9
Piccolo OT:

Sono riuscito a contattare Ron, e forse tornerà su qualche forum per rinfrescare il web con nuovi dati o forse migliorie.

Topic:

Brucina, Stricnina, e Vomicina sono i tre alcaloidi, però ho anche trovato altri modi per fare le tinture.

La brucina(XLop 1) è più solubile in acqua della stricnina(XLogP 1.9), ma entrambe sono 'buone'.

Però mi sono spaventato perchè facendo le mie ricerche un utente di un forum (Longecity), quando doveva riportare i dati della tintura che aveva fatto non ha più risposto, e m'ero un po' bloccato... Però i semi si trovano su qualche sito Tedesco mi sa... prezzi fattibili.

La stricnina è quasi come la scena del film 'Limitless' in cui sente il tichettio della bicicletta mentre 'sale' le scale xD

Altra cosuccia...

DOSE ATTIVA VS DOSE MORTALE

La dose attiva è 500μg quella mortale (la minima che ho trovato) 15mg.


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#10
Con quelli di DMT-Nexus aveva scazzato, sai se posta solo su drugs-forum?
"But how can the one liberate the many? By first liberating his own being. He does this not by elevating himself, but by lowering himself. He lowers himself to that which is simple, modest, true; integrating it into himself, he becomes a master of simplicity, modesty, truth. Completely emancipated from his former false life, he discovers his original pure nature, which is the pure nature of the universe. Freely and spontaneously releasing his divine energy, he constantly transcends complicated situations and draws everything around him back into an integral oneness. Because he is a living divinity, when he acts, the universe acts." Lao Tzu

"It’s too early for a science. What we need now are the diaries of explorers. We need many diaries of many explorers so we can begin to get a feeling for the territory." T. McKenna

"The man who dies before he dies, does not die when he dies." A. a Sancta Clara


ATTENZIONE! Tutti i miei post sono scritti a puro titolo informativo e non vogliono incitare in alcun modo all'utilizzo di sostanze stupefacenti e/o psicotrope!
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#11
Non posta più nemmeno su drug-forum già da un bel po', aveva un forum con altri geni del male 'herbs.mxf.yuku.com', ora posta solo le sue ricerche su herbpedia.wikidot.com.

La Yopo Theory è fresca fresca, ma il sito era in continuo aggiornamento dal 2013 (herpedia).


Strychnine is said to have been the favorite drug of Adolf Hitler, who also appears to have used cocaine (Schmidbauer and vom Scheidt 1984, 260*):
[INDENT]Moreover, we will never know if and how Hitler’s strategy and war leadership might have changed if he had not been making his decisions while in a euphoric trance state induced by high dosages of strychnine. . . . (Irving 1980, 135)






[h=3]Adolf Hitler's medical care
by
Doyle D.
J R Coll Physicians Edinb. 2005 Feb;35(1):75-82

ABSTRACT[/h][INDENT]For the last nine years of his life Adolf Hitler, a lifelong hypochondriac had as his physician Dr Theodor Morell. Hitler's mood swings, Parkinson's disease, gastro-intestinal symptoms, skin problems and steady decline until his suicide in 1945 are documented by reliable observers and historians, and in Morell's diaries. The bizarre and unorthodox medications given to Hitler, often for undisclosed reasons, include topical cocaine, injected amphetamines, glucose, testosterone, estradiol, and corticosteroids. In addition, he was given a preparation made from a gun cleans, a compound of strychnine and atropine, an extract of seminal vesicles, and numerous vitamins and 'tonics'. It seems possible that some of Hitler's behaviour, illnesses and suffering can be attributed to his medical care. Whether he blindly accepted such unorthodox medications or demanded them is unclear.[/INDENT][/INDENT]

Ron ha colto il dettaglio, e in 3D, l'ha segnalato. Atropina e Stricnina tecnicamente dovrebbero bilanciarsi a vicenda, perchè l'atropina a differenza della scopolamina è uno stimolante fisico, ma non altera in modo pesante la memoria, concetrazione come invece la scopolamina fa (questo almeno secondo Ron, e altri studi trovati nel web). Inoltre gli anti-colinergici sembrano molto validi per aumentare la dopamina a disposizione e quindi utili contro il Parkinson. La NASA contro certi disturbi (motor sickness) usa la scopolamina entro certi mg.
Infine, la stricnina essendo un inibitore dell'acetilcolina dovrebbe prevenire 'il rincoglionimento' da anti-colinergici.

Ma senda andere troppo nel rischioso, forse Galantamina, Huperzina, Vinpocetina, Arecolina, Nicotina, Vincamina, Celastrus Paniculatus, Scopolamina e altre dovrebbero ridurre il carico sul sistema colinergici e dare una spinta euforica senza troppi effetti secondari.
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#12
[ATTACH=CONFIG]17200[/ATTACH]

I was blind... but now I see.


Me l'immagino un po' così la salita dell'estratto di Nux-Vomica.
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#13
Primo esperimento: 10mg di nux vomica tostata, tritata e incapsulata. Dopo un'ora e mezza sento che la sostanza sta facendo effetto, ma e' troppo poca per aver un'idea chiara di cosa mi stia facendo. Sento un leggero formicolio nelle braccia e una sensazione di fluttuazione, ma forse e' pura autosuggestione.

Ho appena ingerito 20mg. Vi faro' sapere come prosegue l'esperimento.

EDIT: Nessun effetto marcato, mi sento lucido e presente. Forse la dose e' ancora bassa o forse i miei semi non sono particolarmente attivi.

ATTENZIONE!!! La nux vomica contiene STRICNINA, una sostanza MOLTO velenosa! Poco piu' di un grammo di nux vomica (30mg di stricnina pura) puo' essere una dose LETALE! Non e' una pianta facile da reperire, ma se riuscite a procurarvi dei semi leggete attentamente i post di 69ron! 69ron consiglia di non andare sopra i 110mg!
"But how can the one liberate the many? By first liberating his own being. He does this not by elevating himself, but by lowering himself. He lowers himself to that which is simple, modest, true; integrating it into himself, he becomes a master of simplicity, modesty, truth. Completely emancipated from his former false life, he discovers his original pure nature, which is the pure nature of the universe. Freely and spontaneously releasing his divine energy, he constantly transcends complicated situations and draws everything around him back into an integral oneness. Because he is a living divinity, when he acts, the universe acts." Lao Tzu

"It’s too early for a science. What we need now are the diaries of explorers. We need many diaries of many explorers so we can begin to get a feeling for the territory." T. McKenna

"The man who dies before he dies, does not die when he dies." A. a Sancta Clara


ATTENZIONE! Tutti i miei post sono scritti a puro titolo informativo e non vogliono incitare in alcun modo all'utilizzo di sostanze stupefacenti e/o psicotrope!
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#14
Dajjjeeeeeeeeeeeeeeee Monad <3
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#15
Caffe' + 30mg + 20mg dopo 45min. Mi sono svegliato stanco, ma quando ha iniziato a fare effetto mi sentivo piu' lucido e presente. Aumentero' ancora la dose.
"But how can the one liberate the many? By first liberating his own being. He does this not by elevating himself, but by lowering himself. He lowers himself to that which is simple, modest, true; integrating it into himself, he becomes a master of simplicity, modesty, truth. Completely emancipated from his former false life, he discovers his original pure nature, which is the pure nature of the universe. Freely and spontaneously releasing his divine energy, he constantly transcends complicated situations and draws everything around him back into an integral oneness. Because he is a living divinity, when he acts, the universe acts." Lao Tzu

"It’s too early for a science. What we need now are the diaries of explorers. We need many diaries of many explorers so we can begin to get a feeling for the territory." T. McKenna

"The man who dies before he dies, does not die when he dies." A. a Sancta Clara


ATTENZIONE! Tutti i miei post sono scritti a puro titolo informativo e non vogliono incitare in alcun modo all'utilizzo di sostanze stupefacenti e/o psicotrope!
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#16
Oggi caffe' + 60mg + 20mg dopo un'ora e venti. Mi sentivo piuttosto lucido e presente (ero a una conferenza), ma non e' un effetto che si fa notare. Tra qualche giorno provero' 100mg. Per ora non mi ha convinto e non capisco se la stanchezza che ho sentito negli ultimi giorni sia un effetto collaterale.
"But how can the one liberate the many? By first liberating his own being. He does this not by elevating himself, but by lowering himself. He lowers himself to that which is simple, modest, true; integrating it into himself, he becomes a master of simplicity, modesty, truth. Completely emancipated from his former false life, he discovers his original pure nature, which is the pure nature of the universe. Freely and spontaneously releasing his divine energy, he constantly transcends complicated situations and draws everything around him back into an integral oneness. Because he is a living divinity, when he acts, the universe acts." Lao Tzu

"It’s too early for a science. What we need now are the diaries of explorers. We need many diaries of many explorers so we can begin to get a feeling for the territory." T. McKenna

"The man who dies before he dies, does not die when he dies." A. a Sancta Clara


ATTENZIONE! Tutti i miei post sono scritti a puro titolo informativo e non vogliono incitare in alcun modo all'utilizzo di sostanze stupefacenti e/o psicotrope!
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#17
Se devo dire la mia (con un'altra sostanza, però vabeh) con i 'Celastrus seeds' l'effetto non si avverte tanto, c'è però.

Comunque, non solo 69ron li ha usati, anche rawbeer di drug-forum, quindi non c'è solo il suo report, lo dico per chi magari vede che cito solo 69ron, anche altri hanno usati questi semini.
Anche Toastus da herbs.mxf.yuku.

Inoltre, penso che siano un po' vecchi
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#18
100mg molta chiarezza, lucidita' e attenzione.

110mg poco e niente.

Forse il cibo influisce e forse anche la stanchezza.
"But how can the one liberate the many? By first liberating his own being. He does this not by elevating himself, but by lowering himself. He lowers himself to that which is simple, modest, true; integrating it into himself, he becomes a master of simplicity, modesty, truth. Completely emancipated from his former false life, he discovers his original pure nature, which is the pure nature of the universe. Freely and spontaneously releasing his divine energy, he constantly transcends complicated situations and draws everything around him back into an integral oneness. Because he is a living divinity, when he acts, the universe acts." Lao Tzu

"It’s too early for a science. What we need now are the diaries of explorers. We need many diaries of many explorers so we can begin to get a feeling for the territory." T. McKenna

"The man who dies before he dies, does not die when he dies." A. a Sancta Clara


ATTENZIONE! Tutti i miei post sono scritti a puro titolo informativo e non vogliono incitare in alcun modo all'utilizzo di sostanze stupefacenti e/o psicotrope!
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#19
ho letto con interesse tutto il post...Questa storia della stricnina mi ha fatto pensare molto alla sua associazione con LSD. Ne so molto poco ma da come ho capito è storicamente usata sui cartoni. Non ne so molto ma leggendo questo post comincio a immaginare molte cose... Mi fa pensare molto il fatto che sia attiva a quantità bassisime, quasi microgrammi, e che dia sensazioni stimolanti e al contempo effetti collaterali di malessere. Mi fa pensare ai tipici trip non "puliti", trip cioè che sono chiaramente di LSD ma che hanno qualcosa "che non va" rispetto ad altri trip di qualità molto superiore che dannoviaggi molto piu piacevoli e con meno postumi.... Solo pensieri a caso... però ci stanno...
Nei miei post non voglio incitare l'uso di alcuna sostanza, ma ritengo doveroso condividere le informazioni che ho raccolto con l'esperienza per ridurre al massimo i danni di tali condotte. Sconsiglio vivamente a chiunque di assumere qualsiasi sostanza psicoattiva.
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#20
Se non sbaglio la storia della stricnina e' una leggenda... 69ron:
Citation : Nux vomica is a great admixture for enhancing the effects of a lot of other herbs. It especially goes well with herbs like kava that alter the senses a little. I think the kava mix is the best so far.
It’s great with psychedelics too in small amounts. Despite the false rumors of LSD commonly being laced with strychnine, LSD actually goes very well with a little nux vomica. I think rumors of it being laced with strychnine got started because LSD sometimes has some side effects that are similar to nux vomica, but they are caused by impurities (lysergic acid derivatives), and not actually caused by strychnine.

A good combination is 50 mg of nux vomica with a small dose of morning glory seeds or Hawaiian baby woodrose seeds plus 5 drops of cinnamon bark oil. That is one fantastic combo.

Nux Vomica Basics in Nux Vomica Forum
"But how can the one liberate the many? By first liberating his own being. He does this not by elevating himself, but by lowering himself. He lowers himself to that which is simple, modest, true; integrating it into himself, he becomes a master of simplicity, modesty, truth. Completely emancipated from his former false life, he discovers his original pure nature, which is the pure nature of the universe. Freely and spontaneously releasing his divine energy, he constantly transcends complicated situations and draws everything around him back into an integral oneness. Because he is a living divinity, when he acts, the universe acts." Lao Tzu

"It’s too early for a science. What we need now are the diaries of explorers. We need many diaries of many explorers so we can begin to get a feeling for the territory." T. McKenna

"The man who dies before he dies, does not die when he dies." A. a Sancta Clara


ATTENZIONE! Tutti i miei post sono scritti a puro titolo informativo e non vogliono incitare in alcun modo all'utilizzo di sostanze stupefacenti e/o psicotrope!
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